Dolutegravir Darunavir Dual Therapy |

30/09/2017 · Dolutegravir DTG plus darunavir/ritonavir DRV/r is a simple combination of drugs that has the best genetic barrier to HIV-1 resistance and may be fit for salvage therapy. All HIV-1-infected subjects treated with DTG plus DRV/r between March 2014 and September 2015 in eight Italian centres were included in the analysis. The main metabolic. 16/11/2019 · These studies found that dual therapy with rilpivirine and dolutegravir was noninferior to 3- or 4-drug combination antiretroviral therapy cART. The long-term efficacy, safety, and tolerability of dual therapy, as compared with usual cART, are less clear and require further data. 01/07/2015 · A switch strategy to investigate whether a dual therapy with Ritonavir-boosted RTV Darunavir DRVDolutegravir DTG over 48 weeks is non-inferior to a continuous standard of care therapy with RTV-boosted DRV in combination with 2. Capetti AF, Sterrantino G, Cossu MV, Cenderello G, Cattelan AM, De Socio GV, Rusconi S, Riccardi N, Baldin GM, Cima S, Niero FP, Rizzardini G, Sasset L. Salvage therapy or simplification of salvage regimens with dolutegravir plus ritonavir-boosted darunavir dual therapy in highly cART-experienced subjects: an Italian cohort. Antivir Ther. viral load <50copies/mL, and safety, defined as the emergence of adverse events, of a dual therapy DT with dolutegravir plus boosted darunavir DTGbDRV in these patients. METHODS: These are the results of an observational, multi-center, restrospective study in HIV patients to analyze the effectiveness of DTGbDRV after 24 weeks.

17/01/2019 · BACKGROUND: Dual therapy based on dolutegravir and ritonavir-boosted darunavir DTG/DRV/r is a combination of well-known drugs with a high genetic barrier to HIV resistance. METHOD: A retrospective analysis of all HIV-1 infected treatment-experienced patients who switched to DTG/DRV/r from May 2014 till March 2017 in 4 Polish centres-results of a 48-week treatment. 17/01/2019 · Dual therapy based on dolutegravir and ritonavir-boosted darunavir DTG/DRV/r is a combination of well-known drugs with a high genetic barrier to HIV resistance. The investigated dual therapy was effective and safe. The observed increase in. 29/07/2019 · Dolutegravir plus lamivudine for initial therapy. Dr Pedro Cahn of Fundación Huésped in Buenos Aires presented the latest findings from the ongoing GEMINI 1 and 2 studies, identical phase 3 trials that together enrolled 1433 people in Europe, the Americas, Asia, Australia, Russia and South Africa who were starting HIV treatment for the first. However, among participants who entered the study with less than 200 cells/ml, dual therapy with boosted darunavir and raltegravir was inferior to triple therapy. Overall, the researchers found the safety of both regimens to be similar.

23/10/2015 · Dual therapy using ritonavir-boosted atazanavir Reyataz plus lamivudine has the strongest evidence in its favour, but the dolutegravir dual and monotherapy data presented here are promising. Dropping tenofovir from a regimen can lead to improved kidney function and bone health, he. 27/12/2015 · To date, lightened strategies monotherapy or dual therapy are largely based on PI/r, alone or with an NRTI, NNRTI, INI or maraviroc. 1,2,5 Of all the PI/r used, boosted darunavir darunavir/r has been most widely tested as a monotherapy. 6 There is no direct comparison between darunavir/r and dolutegravir as monotherapy or dual therapy.

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